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Urinary Phthalate Metabolites Are Associated With Decreased Serum Testosterone in Men, Women and, Children From NHANES 2011 - 2012

John, D., Meeker, and, Kelly, K., Ferguson

Context:

There is evidence of declining trends in T levels among men in recent decades, as well as trends in related conditions at multiple life stages and in both sexes. There is also animal and limited human evidence that exposure to phthalates, chemicals found in plastics and personal care products, is associated with reduced androgen levels and associated disorders.

Objective:

To explore relationships between urinary concentrations of metabolites and serum total 13 phthalate T levels among men, women and, children when adjusting for important confounders and stratifying by sex and age (6 - 12, 12 - 20, 20 - 40, 40 - 60, 60 - 80 and Y.

)

Design:

A cross-sectional study,Nike Air VaporMax 2.0 Hot Punch.

Setting:

US, National, Health, and,Nike Kobe, Nutrition, Examination, Survey, 2>

Urinary Phthalate Metabolites Are Associated With Decreased Serum Testosterone in Men, Women, and Children From NHANES 2011–2012

John D. Meeker and Kelly K. Ferguson

Context:

There is evidence of declining trends in T levels among men in recent decades, as well as trends in related conditions at multiple life stages and in both sexes. There is also animal and limited human evidence that exposure to phthalates,Nike LeBron 15 Hollywood Scarpe Packaging paper can be a gift skirt, American fashion desi, chemicals found in plastics and personal care products, is associated with reduced androgen levels and associated disorders.

Objective:

To explore relationships between urinary concentrations of 13 phthalate metabolites and serum total T levels among men, women, and children when adjusting for important confounders and stratifying by sex and age (6–12, 12–20, 20–40, 40–60, and 60–80 y).

Design:

A cross-sectional study.

Setting:

US National Health and Nutrition Examination Survey, 2011–2012.

Patients or Other Participants:

US general population.

Interventions:

None

Main Outcome Measures:

Serum total T measured by isotope dilution-liquid chromatography-tandem mass spectrometry.

Results:

Multiple phthalates were associated with significantly reduced T in both sexes and in differing age groups. In females, the strongest and most consistent inverse relationships were found among women ages 40–60 years. In boys 6–12 years old, an interquartile range increase in metabolites of di-2-ethylhexyl phthalate was associated with a 29% (95% confidence interval, 6, 47) reduction in T. In adult men,Palm reading released the second generation of electronic paper book iReader Plus price 999 yuan _ S, the only significant or suggestive inverse associations between phthalates (metabolites of di-2-ethylhexyl phthalate and dibutyl phthalate) and T were observed among men ages 40–60 years.

Conclusions:

Because T plays an important role in all life stages for both sexes, future efforts should focus on better defining these relationships and their broader impacts.


 
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